Impact of Gestational Diabetes and Pre-existing Diabetes in Fetal Outcome among Pregnancy Cases of Rangpur

Authors

  • Nahida Sultana Assistant professor, Department of Anesthesiology, Prime Medical College Hospital,Rangpur, Bangladesh

DOI:

https://doi.org/10.61561/ssbj.v4i4.42

Keywords:

Gestational Diabetes, Pre-gestational Diabetes, Pregnancy, Fetal Outcomes, Stillbirth

Abstract

Introduction: Diabetes in pregnancy, including gestational and pre-gestational diabetes, presents significant risks to both maternal and fetal health. Understanding the impact of these conditions on pregnancy outcomes is crucial for developing effective management strategies.

Methods: This observational comparative study involved 300 pregnant women at Rangpur Medical College Hospital, divided into three groups: pre-gestational diabetic (Group A), gestational diabetic (Group B), and non-diabetic control (Group C). Data on socio-demographic characteristics, obstetric profiles, mode of delivery, maternal complications, and fetal outcomes were collected and analyzed.

Result: The study meticulously analyzed socio-demographic characteristics, revealing no significant differences across the groups. In obstetric profiles, Group A (Pre-Gestational Diabetic) had a notably lower mean gestational age at delivery (36.06 ± 2.71 weeks) compared to Group B (Gestational Diabetic) and Group C (Control), with mean ages of 37.34± 1.12 and 38.46±1.13 weeks, respectively. Maternal complications were significantly higher in Group A at 47%, compared to 25% in Group B and 12% in Group C. Fetal outcomes showed marked variations: Group A had 95% stable births, 5% stillbirths, and 60% of neonates with Apgar scores ≤7 at 5 minutes. In contrast, Group B had 96% stable births, 4% stillbirths, and 27% of neonates with Apgar scores ≤7, while Group C reported 100% stable births and 11% with Apgar scores ≤7. Birth weight distribution indicated 24% of neonates in Group A weighed <2 kg, compared to 5% in Group B and 4% in Group C. NICU admissions were highest in Group A (44%), followed by Group B (29%) and Group C (11%). Perinatal complications like birth asphyxia (38% in Group A, 16% in Group B, 6% in Group C), hypoglycemia (22% in Group A, 10% in Group B, 4% in Group C), and hyperbilirubinemia (16% in Group A, 12% in Group B, 0% in Group C) were also significantly higher in diabetic groups.

Conclusion: The presence of gestational or pre-gestational diabetes in mothers significantly impacts fetal outcomes and increases the risk of maternal complications. This study highlights the need for specialized care and vigilant monitoring in pregnancies complicated by diabetes to improve health outcomes for mothers and babies.

 

References

Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2010 Jan [cited 2024 Jan 30];33(Suppl 1):S62–9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797383/

Dahiya K, Sahu J, Dahiya A. Maternal and Fetal Outcome in Gestational Diabetes Mellitus—A Study at Tertiary Health Centre in Northern India. Open Access Library Journal. 2014 Jun 30 [cited 2024 Jan 30];1(3):1–5. Available from: https://www.scirp.org/journal/paperinformation.aspx?paperid=64123

Sultana N, Shermin S, Naher N, Ferdous F, Farjana S. Diabetes in Pregnancy: Maternal Profile and Neonatal Outcome. Delta Medical College Journal. 2016 Aug 19 [cited 2024 Jan 30];4(2):83–8. Available from: https://banglajol.info/index.php/DMCJ/article/view/29379

Wahabi H, Fayed A, Esmaeil S, Mamdouh H, Kotb R. Prevalence and Complications of Pregestational and Gestational Diabetes in Saudi Women: Analysis from Riyadh Mother and Baby Cohort Study (RAHMA). Biomed Res Int. 2017;2017:6878263.

Das AC, Azad MT, Nazme NI, Chowdhury JF, Rahman Z, Rahman F. Incidence and Glycemic Status of Infants of Diabetic Mothers among 189 Hospitalized Low Birth Weight Babies. Delta Medical College Journal. 2017 Feb 4 [cited 2024 Jan 30];5(1):4–8. Available from: https://www.banglajol.info/index.php/DMCJ/article/view/31420

Shukla A, Burute S, Meena A. Maternal and fetal outcome in gestational diabetes – A retrospective study. International journal of applied research. 2017 Sep 1 [cited 2024 Jan 30]. Available from: https://www.semanticscholar.org/paper/Maternal-and-fetal-outcome-in-gestational-diabetes-Shukla-Burute/4a99e43f335cd951fd0bed3498e66a21e12cdcf6

Ben-Haroush A, Yogev Y, Hod M. Epidemiology of gestational diabetes mellitus and its association with Type 2 diabetes. Diabet Med. 2004 Feb;21(2):103–13.

Kaaja R, Rönnemaa T. Gestational diabetes: pathogenesis and consequences to mother and offspring. Rev Diabet Stud. 2008;5(4):194–202.

Wahabi H. Maternal and Perinatal Outcomes of Pregnancies Complicated with Pregestational and Gestational Diabetes Mellitus in Saudi Arabia. Journal of Diabetes & Metabolism. 2014 Jan 1;05.

Syiemleh AJ, Pradhan B, Devi P. Clinical Study of Fetomaternal Outcome of Gestational Diabetes Mellitus. In 2015 [cited 2024 Jan 30]. Available from: https://www.semanticscholar.org/paper/Clinical-Study-of-Fetomaternal-Outcome-of-Diabetes-Syiemleh-Pradhan/127722189d3ab17492a849f3e21d1eb1bef11f6d

Nili F, MAHDAVIANI A. COMPARISON OF MORBIDITIES BETWEEN INFANTS OF PREGESTATIONAL & GESTATIONAL DIABETIC MOTHERS. MJIRI. 2004 Jan 1;

Arias F, Bhide AG, S A, Damania K, Daftary SN. Practical Guide to High Risk Pregnancy and Delivery - E-Book: A South Asian Perspective. Elsevier Health Sciences; 2008. 583 p.

Dutta DC. Medical and surgical illness complicating pregnancy. Textbook of Obstetrics. 2004;6:262–305.

Groof Z, Garashi G, Husain H, Owayed S, AlBader S, Mouhsen H, et al. Prevalence, Risk Factors, and Fetomaternal Outcomes of Gestational Diabetes Mellitus in Kuwait: A Cross-Sectional Study. Journal of Diabetes Research. 2019 Mar 3;2019:1–7.

Jubrael NJ, Alalaf SK, Shabila N, Ali SA. Gestational diabetes and its correlation with maternal socio-demographic characteristics. Zanco Journal of Medical Sciences (Zanco J Med Sci). 2022 Dec 15 [cited 2024 Jan 30];26(3):194–202. Available from: https://zjms.hmu.edu.krd/index.php/zjms/article/view/832

Sofiah ZA, Maslinda Z, Norhasimah MI. THE SOCIO-DEMOGRAPHY CHARACTERISTICS AND THE OUTCOMES OF GESTATIONAL DIABETES PATIENTS DAERAH HULU PERAK IN JANUARY – DECEMBER 2017. electronic - Perak Medical Journal. 2019 Jun 21 [cited 2024 Jan 30];1(Supp 01). Available from: https://myjms.mohe.gov.my/index.php/pmj/article/view/5975

Zhang Z, Mei L, Li L, Xiao J, Wu X, Yuan Y. Maternal and neonatal outcomes of twin pregnancies complicated by gestational diabetes mellitus. Endocrine. 2023 Nov 10 [cited 2024 Jan 9]. Available from: https://doi.org/10.1007/s12020-023-03588-0

Ghosh A, Saha SK. ADVERSE PREGNANCY OUTCOMES IN GESTATIONAL DIABETES MELLITUS - STUDY IN AN APEX HOSPITAL. 2012;2.

Jin M, Liu X, Liu X, Wu Y, Zhang Y, Zhang L, et al. Association of pre-/early pregnancy high blood pressure and pregnancy outcomes: a systemic review and meta-analysis. The Journal of Maternal-Fetal & Neonatal Medicine. 2024 Jan 2 [cited 2024 Jan 30];37(1):2296366. Available from: https://doi.org/10.1080/14767058.2023.2296366

Glick I, Kadish E, Rottenstreich M. Management of Pregnancy in Women of Advanced Maternal Age: Improving Outcomes for Mother and Baby. IJWH. 2021 Aug 10 [cited 2024 Jan 30];13:751–9. Available from: https://www.dovepress.com/management-of-pregnancy-in-women-of-advanced-maternal-age-improving-ou-peer-reviewed-fulltext-article-I

Downloads

Published

2023-12-27
CITATION
DOI: 10.61561/ssbj.v4i4.42
Published: 2023-12-27

How to Cite

Nahida Sultana. (2023). Impact of Gestational Diabetes and Pre-existing Diabetes in Fetal Outcome among Pregnancy Cases of Rangpur. SSB Global Journal of Medical Science, 4(4), 6–12. https://doi.org/10.61561/ssbj.v4i4.42

Issue

Section

Original Research Article